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Janus kinase inhibitors: A therapeutic strategy for cancer and autoimmune diseases

18 Feb 2020

Abstract excerpt

Many cytokines are crucial drivers of cancers and autoimmune conditions. These proteins bind to receptors and signal their responses through Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathways. Genetic variations in the JAK-STAT pathway are correlated with the increased risk of cancers, autoimmunity as well as inflammatory diseases. Targeting JAKs and STATs can be a safe and...

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PMID: 32072644
DOI: 10.1002/jcp.29593

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