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Article

JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis

19 Dec 2019

Abstract excerpt

Janus kinase (JAK) inhibitors are widely used in the treatment of multiple autoimmune and inflammatory diseases. Immunologic and transcriptomic profiling have revealed major alterations on natural killer (NK) cell homeostasis associated with JAK inhibitions, while information on other innate lymphoid cells (ILCs) is still lacking. Herein, we observed that, in mice, the homeostatic pool of liver ILC1 was less...

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PMID: 31921209
DOI: 10.3389/fimmu.2019.02972

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