Article
Responses to Cytokines and Interferons that Depend upon JAKs and STATs.
Cold Spring Harbor perspectives in biology - 2 Jan 2018
Stark George R, Cheon HyeonJoo, Wang Yuxin
Abstract excerpt
Many cytokines and all interferons activate members of a small family of kinases (the Janus kinases [JAKs]) and a slightly larger family of transcription factors (the signal transducers and activators of transcription [STATs]), which are essential components of pathways that induce the expression of specific sets of genes in susceptible cells. JAK-STAT pathways are required for many innate and acquired immune...
Topics
- Animals
- Chromatin Assembly and Disassembly
- Cytokines
- Gene Expression Regulation
- Glycosylation
- Humans
- Interferons
- Janus Kinases
- Mutation
- Phosphorylation
- STAT Transcription Factors