Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The JAK/STAT conundrum with mutational heterogeneity, immune defects, and the emergence of targeted therapies.

Expert review of clinical immunology - 1 Aug 2025

Demirkaya Durmus Burak, Colak Burkay Cagan, Sefer Asena Pinar, Baris Safa

Abstract excerpt

INTRODUCTION: The Janus kinase/signal transducer and activator of transcription signaling pathway orchestrates crucial aspects of immune regulation, including cytokine signaling, cellular proliferation, differentiation, and apoptosis. Dysregulation of this pathway due to gain- or loss-of-function mutations significantly contributes to the development of inborn errors of immunity and various immune-mediated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to STAT6 gene
Share to Immune System Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinases

Share to Molecular Targeted Therapy

Share to Mutation

Share to Precision Medicine

Share to Signal Transduction

Share to STAT Transcription Factors

Source

Identifiers

PMID: 40844826
DOI: 10.1080/1744666X.2025.2543475

Genes

STAT1
STAT3
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The JAK/STAT conundrum with mutational heterogeneity, immune defects, and the emergence of targeted therapies.PMID 40844826Read ↗

JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition.Semantic proximity Read ↗

JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional ConsequencesSemantic proximity Read ↗

Human diseases caused by impaired signal transducer and activator of transcription and Janus kinase signaling.Semantic proximity Read ↗

STAT wars: how STATopathies sabotage innate immunity.Semantic proximity Read ↗

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic InterventionSemantic proximity Read ↗

The Goldilocks Principle of JAKs and STATs: Gain-of function mutations, loss-of-function mutations, and their clinical consequencesSemantic proximity Read ↗

Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity Disrupted in Immune Cell Cancer and ImmunodeficiencySemantic proximity Read ↗

STAT1 and STAT3 mutations: important lessons for clinical immunologistsSemantic proximity Read ↗

Unraveling the Immunogenetics of STAT Proteins: Clinical Perspectives on Gain-of-Function and Loss-of-Function Variants.Semantic proximity Read ↗

Responses to Cytokines and Interferons that Depend upon JAKs and STATs.Semantic proximity Read ↗

JAKs and STATs in immunity, immunodeficiency, and cancer.Semantic proximity Read ↗

Series Introduction: JAK-STAT signaling in human diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.