Article
The abundance of cis-acting loci leading to differential allele expression in F1 mice and their relationship to loci harboring genes affecting complex traits.
BMC genomics - 11 Aug 2016
Yeo Seungeun, Hodgkinson Colin A, Zhou Zhifeng, Jung Jeesun, Leung Ming, Yuan Qiaoping, Goldman David
Abstract excerpt
BACKGROUND: Genome-wide surveys have detected cis-acting quantitative trait loci altering levels of RNA transcripts (RNA-eQTLs) by associating SNV alleles to transcript levels. However, the sensitivity and specificity of detection of cis- expression quantitative trait loci (eQTLs) by genetic approaches, reliant as it is on measurements of transcript levels in recombinant inbred strains or offspring from arranged...
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