Article
MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions.
Arthritis research & therapy - 9 Apr 2020
Wang Geng, Kim Tae-Hwan, Li Zhixiu, Cortes Adrian, Kim Kwangwoo, Bang So-Young, Leo Paul, Brown Matthew A, Xu Huji
Abstract excerpt
BACKGROUND: The association of HLA-B*27 with AS is amongst the strongest of any known association of a common variant with any human disease. Nonetheless, there is strong evidence indicating that other HLA-B alleles are involved in the disease. European ethnicity studies have demonstrated risk associations with HLA-B*40 and multiple other HLA-B, HLA-A, and HLA class II alleles, and demonstrated that in that...
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