Article
Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis.
RMD open - 1 Aug 2023
Braun Juergen, Sieper Joachim
Abstract excerpt
The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility. Its prevalence in the mid-European population is about 8%. The association of HLA B27 alleles with ankylosing spondylitis (AS), a highly heritable disease, which is part of the spectrum of axial...
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