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Article

How Reliable Are the Reported Genetic Associations in Disc Degeneration?: The Influence of Phenotypes, Age, Population Size, and Inclusion Sequence in 809 Patients.

Spine - 1 Nov 2016

Rajasekaran S, Kanna Rishi Mugesh, Reddy Ranjani Raja, Natesan Senthil, Raveendran Muthuraja, Cheung Kenneth M C, Chan Danny, Kao Patrick Y P, Yee Anita, Shetty Ajoy Prasad

Abstract excerpt

STUDY DESIGN: Prospective genetic association study. OBJECTIVE: The aim of this study was to document the variations in the genetic associations, when different magnetic resonance imaging (MRI) phenotypes, age stratification, cohort size, and sequence of cohort inclusion are varied in the same study population. SUMMARY OF BACKGROUND DATA: Genetic associations with disc degeneration have shown high inconsistency,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27513226
DOI: 10.1097/BRS.0000000000001847

Genes

MMP20
ADAMTS5
CALM1
CILP
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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