Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes.

PloS one - 1 Jan 2017

Perera Romain Shanil, Dissanayake Poruwalage Harsha, Senarath Upul, Wijayaratne Lalith Sirimevan, Karunanayake Aranjan Lional, Dissanayake Vajira Harshadeva Weerabaddana

Abstract excerpt

INTRODUCTION: Lumbar disc degeneration (LDD) is genetically determined and severity of LDD is associated with Modic changes. Aggrecan is a major proteoglycan in the intervertebral disc and end plate. Progressive reduction of aggrecan is a main feature of LDD and Modic changes. OBJECTIVES: The study investigated the associations of single nucleotide variants (SNVs) of candidate genes in the aggrecan metabolic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aggrecans
Share to Chronic Pain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1alpha

Share to Intervertebral Disc Degeneration

Share to Intervertebral Disc Displacement

Share to Low Back Pain

Share to Polymorphism, Single Nucleotide

Share to Tissue Inhibitor of Metalloproteinase-3

Source

Open in PubMed Open full text

Identifiers

PMID: 28081267
DOI: 10.1371/journal.pone.0169835
PMCID: PMC5231268

Genes

ADAMTS4
ADAMTS5
ACAN
TIMP3
MMP3
TIMP1
TIMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes.PMID 28081267Read ↗

Variants of ACAN are associated with severity of lumbar disc herniation in patients with chronic low back pain.Semantic proximity Read ↗

Genetic susceptibility of lumbar degenerative disc disease in young Indian adults.Semantic proximity Read ↗

How Reliable Are the Reported Genetic Associations in Disc Degeneration?: The Influence of Phenotypes, Age, Population Size, and Inclusion Sequence in 809 Patients.Semantic proximity Read ↗

Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing.Semantic proximity Read ↗

Treatment outcome of chronic low back pain and radiographic lumbar disc degeneration are associated with inflammatory and matrix degrading gene variants: a prospective genetic association study.Semantic proximity Read ↗

Genetic Alterations in Intervertebral Disc DiseaseSemantic proximity Read ↗

A Whole Exome Study Identifies Novel Candidate Genes for Vertebral Bone Marrow Signal Changes (Modic Changes).Semantic proximity Read ↗

Meta-analysis of the effects of genetic polymorphisms on intervertebral disc degeneration.Semantic proximity Read ↗

Genetic association studies in lumbar disc degeneration: a systematic review.Semantic proximity Read ↗

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations.Semantic proximity Read ↗

Polymorphisms within the COL5A1 gene and regulators of the extracellular matrix modify the risk of Achilles tendon pathology in a British case-control study.Semantic proximity Read ↗

Phenotype variations affect genetic association studies of degenerative disc disease: conclusions of analysis of genetic association of 58 single nucleotide polymorphisms with highly specific phenotypes for disc degeneration in 332 subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.