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Article

Genetic polymorphisms associated with intervertebral disc degeneration.

The spine journal : official journal of the North American Spine Society - 1 Mar 2013

Mayer Jillian E, Iatridis James C, Chan Danny, Qureshi Sheeraz A, Gottesman Omri, Hecht Andrew C

Abstract excerpt

BACKGROUND CONTEXT: Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of the intervertebral discs and can lead to painful conditions. The pathophysiology of degeneration is not well understood, but previous studies suggest that certain genetic polymorphisms may be important contributing factors leading to an increased risk of DD. PURPOSE: To review the genetic factors...

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Source

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Identifiers

PMID: 23537453
DOI: 10.1016/j.spinee.2013.01.041
PMCID: PMC3655694

Genes

CILP
GDF5
HAPLN1
MMP1
MMP3
PSMB9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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