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Article

Genetic association studies in lumbar disc degeneration: a systematic review.

PloS one - 1 Jan 2012

Eskola Pasi J, Lemmelä Susanna, Kjaer Per, Solovieva Svetlana, Männikkö Minna, Tommerup Niels, Lind-Thomsen Allan, Husgafvel-Pursiainen Kirsti, Cheung Kenneth M C, Chan Danny, Samartzis Dino, Karppinen Jaro

Abstract excerpt

OBJECTIVE: Low back pain is associated with lumbar disc degeneration, which is mainly due to genetic predisposition. The objective of this study was to perform a systematic review to evaluate genetic association studies in lumbar disc degeneration as defined on magnetic resonance imaging (MRI) in humans. METHODS: A systematic literature search was conducted in MEDLINE, MEDLINE In-Process, SCOPUS, ISI Web of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23185509
DOI: 10.1371/journal.pone.0049995
PMCID: PMC3503778

Genes

ASPN
COL11A1
GDF5
MMP9
THBS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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