Article
In vitro studies identify a low replication phenotype for hepatitis B virus genotype H generally associated with occult HBV and less severe liver disease.
Virology - 1 Jun 2018
Sozzi Vitina, Shen Fang, Chen Jieliang, Colledge Danni, Jackson Kathy, Locarnini Stephen, Yuan Zhenghong, Revill Peter A
Abstract excerpt
Hepatitis B virus (HBV) exists as 9 major genotypes and multiple subtypes, many of which exhibit differences in pathogenicity and treatment response. Genotype H identified in Central America is associated with low incidence of liver disease and HCC, but higher incidence of occult HBV (low level HBV DNA positivity, HBsAg negative). The replication phenotype of genotype H associated with less severe forms of liver...
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