Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles.

Genome research - 1 Oct 2016

Aldrup-MacDonald Megan E, Kuo Molly E, Sullivan Lori L, Chew Kimberline, Sullivan Beth A

Abstract excerpt

Alpha satellite is a tandemly organized type of repetitive DNA that comprises 5% of the genome and is found at all human centromeres. A defined number of 171-bp monomers are organized into chromosome-specific higher-order repeats (HORs) that are reiterated thousands of times. At least half of all human chromosomes have two or more distinct HOR alpha satellite arrays within their centromere regions. We previously...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Centromere
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to DNA, Satellite

Share to Genomic Instability

Share to HCT116 Cells

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27510565
DOI: 10.1101/gr.206706.116
PMCID: PMC5052062

Genes

CENPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles.PMID 27510565Read ↗

α satellite DNA variation and function of the human centromere.Semantic proximity Read ↗

Functional epialleles at an endogenous human centromere.Semantic proximity Read ↗

The variation and evolution of complete human centromeresSemantic proximity Read ↗

Rich polymorphic variants of alpha satellite 34mer higher order repeats in hg38 assembly of human chromosome YSemantic proximity Read ↗

Alpha satellite insertion close to an ancestral centromeric regionSemantic proximity Read ↗

The variation and evolution of complete human centromeres.Semantic proximity Read ↗

Multidimensional variation and population stratification across 8000 complete human centromeresSemantic proximity Read ↗

Classification and monomer-by-monomer annotation of suprachromosomal family 1 alpha satellite higher-order repeats in hg38 human genome assemblySemantic proximity Read ↗

A global view of human centromere variation and evolutionSemantic proximity Read ↗

A Game of Thrones at Human Centromeres I. Multifarious structure necessitates a new molecular/evolutionary modelSemantic proximity Read ↗

Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNASemantic proximity Read ↗

Long-read Data Revealed Structural Diversity in Human Centromere SequencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.