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Article

Functional epialleles at an endogenous human centromere.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2012

Maloney Kristin A, Sullivan Lori L, Matheny Justyne E, Strome Erin D, Merrett Stephanie L, Ferris Alyssa, Sullivan Beth A

Abstract excerpt

Human centromeres are defined by megabases of homogenous alpha-satellite DNA arrays that are packaged into specialized chromatin marked by the centromeric histone variant, centromeric protein A (CENP-A). Although most human chromosomes have a single higher-order repeat (HOR) array of alpha satellites, several chromosomes have more than one HOR array. Homo sapiens chromosome 17 (HSA17) has two juxtaposed HOR...

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Identifiers

PMID: 22847449
DOI: 10.1073/pnas.1203126109
PMCID: PMC3427087

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