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Article

The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas.

Cell and tissue research - 1 Sept 2016

Mezawa Yoshihiro, Orimo Akira

Abstract excerpt

Carcinoma-associated fibroblasts (CAFs) constitute a substantial proportion of the non-neoplastic mesenchymal cell compartment in various human tumors. These fibroblasts are phenotypically converted from their progenitors via interactions with nearby cancer cells during the course of tumor progression. The resulting CAFs, in turn, support the growth and progression of carcinoma cells. These fibroblasts have a...

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PMID: 27506216
DOI: 10.1007/s00441-016-2471-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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