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Plasticity and Functional Heterogeneity of Cancer-Associated Fibroblasts

29 Jul 2025

Abstract excerpt

Tumor heterogeneity and plasticity enable adaptation to metastatic microenvironments and resistance to therapies. Recent progress in single-cell analyses has permitted detailed characterization of the complexity and diversity of the different tumor components in multiple tumor types. Cancer-associated fibroblasts (CAF) are a central component of the tumor microenvironment and play critical roles in cancer...

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PMID: 40729489
DOI: 10.1158/0008-5472.can-24-3037

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