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Article

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression

25 Oct 2009

Abstract excerpt

Tumours are highly complex tissues composed of carcinoma cells and surrounding stroma, which is constructed by various different types of mesenchymal cells and an extracellular matrix (ECM). Carcinoma-associated fibroblasts (CAFs), which consist of both fibroblasts and myofibroblasts, are frequently observed in the stroma of human carcinomas, and their presence in large numbers is often associated with the...

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PMID: 19857592
DOI: 10.1016/j.semcdb.2009.10.002

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