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Article

Phenotypic heterogeneity, stability and plasticity in tumor-promoting carcinoma-associated fibroblasts.

The FEBS journal - 1 May 2022

Mezawa Yoshihiro, Orimo Akira

Abstract excerpt

Reciprocal interactions between cancer cells and stromal cells in the tumor microenvironment (TME) are essential for full-blown tumor development. Carcinoma-associated fibroblasts (CAFs) are a key component of the TME together with a wide variety of stromal cell types including vascular, inflammatory, and immune cells in the extracellular matrix. CAFs not only promote tumor growth, invasion, and metastasis, but...

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PMID: 33786982
DOI: 10.1111/febs.15851

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