Article
Murine Flt3 ligand-generated plasmacytoid and conventional dendritic cells display functional differentiation in activation, inflammation, and antigen presentation during BCG infection in vitro.
In vitro cellular & developmental biology. Animal - 1 Jan 2017
Meng Chuang, Wang Xiaoyan, Xu Zhengzhong, Hu Maozhi, Liu Jiaying, Pan Zhiming, Chen Xiang, Jiao Xinan
Abstract excerpt
Dendritic cells (DCs) are composed of distinct subsets. Their immunologic functions (especially in pathogenic infection, such as with mycobacteria) are poorly understood, largely because of their rarity and difficulty of preparation. We used the murine Fms-like tyrosine kinase 3 (Flt3) ligand to generate conventional DCs (FL-cDCs) and plasmacytoid DCs (FL-pDCs) and further evaluated their immunological responses...
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