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Article

Mycobacterium tuberculosis RpfB drives Th1-type T cell immunity via a TLR4-dependent activation of dendritic cells.

Journal of leukocyte biology - 1 Oct 2013

Kim Jong-Seok, Kim Woo Sik, Choi Han-Gyu, Jang Byungki, Lee Keehoon, Park Jong-Hwan, Kim Hwa-Jung, Cho Sang-Nae, Shin Sung Jae

Abstract excerpt

The failure of Mycobacterium bovis BCG as a TB vaccine against TB reactivation suggests that latency-associated proteins should be included in alternative TB vaccine development. Further, antigens known to generate protective immunity against the strong Th1 stimulatory response to reactivated TB should be included in novel vaccine design. Recent studies have emphasized the importance of Rpfs from Mycobacterium...

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Source

Identifiers

PMID: 23825389
DOI: 10.1189/jlb.0912435

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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