Article
Using dendritic cells to evaluate how Burkholderia cenocepacia clonal isolates from a chronically infected cystic fibrosis patient subvert immune functions.
Medical microbiology and immunology - 1 Apr 2017
Guadalupe Cabral M, Pereira Marília, Silva Zélia, Iria Inês, Coutinho Carla, Lopes Andreia, Sá-Correia Isabel, Videira Paula A
Abstract excerpt
Infection with Burkholderia cepacia complex (Bcc) bacteria is a threat to cystic fibrosis (CF) patients, commonly leading to a fatal pneumonia, the cepacia syndrome. It causes a massive production of pro-inflammatory cytokines and leucocyte recruitment to airway epithelium without resolving infection and contributing to tissue lesion. To dissect how Bcc bacteria subvert the immune response, we developed a...
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