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Article

Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors.

PloS one - 1 Jan 2011

Pavlovicz Ryan E, Henderson Brandon J, Bonnell Andrew B, Boyd R Thomas, McKay Dennis B, Li Chenglong

Abstract excerpt

Acetylcholine-based neurotransmission is regulated by cationic, ligand-gated ion channels called nicotinic acetylcholine receptors (nAChRs). These receptors have been linked to numerous neurological diseases and disorders such as Alzheimer's disease, Parkinson's disease, and nicotine addiction. Recently, a class of compounds has been discovered that antagonize nAChR function in an allosteric fashion. Models of...

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Identifiers

PMID: 21949802
DOI: 10.1371/journal.pone.0024949
PMCID: PMC3174232

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