Article
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.
Nature structural & molecular biology - 1 Jul 2005
Celie Patrick H N, Kasheverov Igor E, Mordvintsev Dmitry Y, Hogg Ronald C, van Nierop Pim, van Elk René, van Rossum-Fikkert Sarah E, Zhmak Maxim N, Bertrand Daniel, Tsetlin Victor, Sixma Titia K, Smit August B
Abstract excerpt
Conotoxins (Ctx) form a large family of peptide toxins from cone snail venoms that act on a broad spectrum of ion channels and receptors. The subgroup alpha-Ctx specifically and selectively binds to subtypes of nicotinic acetylcholine receptors (nAChRs), which are targets for treatment of several neurological disorders. Here we present the structure at a resolution of 2.4 A of alpha-Ctx PnIA (A10L D14K), a potent...
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