Article
Stable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonists.
British journal of pharmacology - 1 May 2011
Capelli Anna Maria, Castelletti Laura, Chen Yu Hua, Van der Keyl Harjeet, Pucci Luca, Oliosi Beatrice, Salvagno Cristian, Bertani Barbara, Gotti Cecilia, Powell Andrew, Mugnaini Manolo
Abstract excerpt
BACKGROUND AND PURPOSE: Despite growing evidence that inhibition of α6β2-containing (α6β2*) nicotinic acetylcholine receptors (nAChRs) may be beneficial for the therapy of tobacco addiction, the lack of good sources of α6β2*-nAChRs has delayed the discovery of α6β2-selective antagonists. Our aim was to generate a cell line stably expressing functional nAChRs with α6β2 properties, to enable pharmacological...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.