Article

Heteropentameric architecture predisposes functional inequivalence of acetylcholine receptor agonist sites

2025-09-15

Abstract excerpt

Muscle-type acetylcholine receptors are heteropen-tameric ion channels composed of four different but evolutionarily related subunits. These subunits assemble with a precise stoichiometry and arrangement, such that two distinct agonist-binding sites are formed at interfaces between a principal α-subunit and a complementary δ or ε/γ-subunit. Chemical differences between the two complementary subunits are presumed t...

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Literature Corpus work: fd16c745-a5be-5931-b7bb-60afaaffc358
DOI: 10.1101/2025.09.13.676060

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