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Article

Interactions of Globular and Ribbon [γ4E]GID with α4β2 Neuronal Nicotinic Acetylcholine Receptor.

Marine drugs - 26 Aug 2021

Wu Xiaosa, Craik David J, Kaas Quentin

Abstract excerpt

The α4β2 nAChR is implicated in a range of diseases and disorders including nicotine addiction, epilepsy and Parkinson's and Alzheimer's diseases. Designing α4β2 nAChR selective inhibitors could help define the role of the α4β2 nAChR in such disease states. In this study, we aimed to modify globular and ribbon α-conotoxin GID to selectively target the α4β2 nAChR through competitive inhibition of the α4(+)β2(-) or...

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Identifiers

PMID: 34564144
DOI: 10.3390/md19090482
PMCID: PMC8469569

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