A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.

doi:10.1053/j.gastro.2016.06.051

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Article

A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.

Gastroenterology - 1 Oct 2016

Li Dalin, Achkar Jean-Paul, Haritunians Talin, Jacobs Jonathan P, Hui Ken Y, D'Amato Mauro, Brand Stephan, Radford-Smith Graham, Halfvarson Jonas, Niess Jan-Hendrik, Kugathasan Subra, Büning Carsten, Schumm L Philip, Klei Lambertus, Ananthakrishnan Ashwin, Aumais Guy, Baidoo Leonard, Dubinsky Marla, Fiocchi Claudio, Glas Jürgen, Milgrom Raquel, Proctor Deborah D, Regueiro Miguel, Simms Lisa A, Stempak Joanne M, Targan Stephan R, Törkvist Leif, Sharma Yashoda, Devlin Bernie, Borneman James, Hakonarson Hakon, Xavier Ramnik J, Daly Mark, Brant Steven R, Rioux John D, Silverberg Mark S, Cho Judy H, Braun Jonathan, McGovern Dermot P B, Duerr Richard H

Abstract excerpt

BACKGROUND & AIMS: Genome-wide association studies have identified 200 inflammatory bowel disease (IBD) loci, but the genetic architecture of Crohn's disease (CD) and ulcerative colitis remain incompletely defined. Here, we aimed to identify novel associations between IBD and functional genetic variants using the Illumina ExomeChip (San Diego, CA). METHODS: Genotyping was performed in 10,523 IBD cases and 5726...

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Identifiers

PMID: 27492617
DOI: 10.1053/j.gastro.2016.06.051
PMCID: PMC5037008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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