Article

Integrative metagenomics and structural bioinformatics identify explainable gut microbial variants associated with Crohn’s disease

2025-12-29

Abstract excerpt

Metagenomics has revealed disease-associated shifts in microbial taxa and functions in inflammatory bowel disease (IBD) patients. However, the role of genomic variation in gut commensals remains poorly understood. Here, we integrated metagenomic profiling, variant calling, and structural bioinformatics to identify disease-associated variants in the gut microbes. Crohn’s disease (CD) and ulcerative colitis (UC) sho...

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Literature Corpus work: 7a9e0123-495e-5b09-8244-4dbbe8d0a5f8
DOI: 10.64898/2025.12.29.696894

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