Article

The ZIP8 A391T Crohn’s disease-linked risk variant induces colonic metal ion dyshomeostasis, microbiome compositional shifts, and inflammation

2024-08-19

Abstract excerpt

<h4>ABSTRACT</h4> The pathogenesis of Crohn’s disease involves genetic and environmental factors, with the gut microbiome playing a crucial role. The Crohn’s disease-associated variant rs13107325 in the SLC39A8 gene results in an A391T substitution in the ZIP8 metal ion transporter and has previously been linked to alterations in the colonic microbiome in variant carriers. We hypothesized that the A391T substitut...

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Literature Corpus work: 3ccad1c0-bac2-5286-96d2-93c8f69afb03
DOI: 10.1101/2024.08.19.608695

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