Article

Metal transporter SLC39A14/ZIP14 modulates regulation between the gut microbiome and host metabolism

2021-12-23

Abstract excerpt

Zinc (Zn) plays a critical role in maintaining intestinal homeostasis by regulating intestinal epithelial cells, host immune cells, and gut microbiome community composition. Deletion of metal transporter Slc39a14/Zip14 causes spontaneous intestinal permeability with low-grade chronic inflammation, mild hyperinsulinemia, and greater body fat with insulin resistance in adipose, suggesting a role for ZIP14-mediated...

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Literature Corpus work: a353009f-6d98-54c4-bf78-ab33f3bafd2b
DOI: 10.1101/2021.12.22.473859

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