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Article

Integrative metagenomics and structural bioinformatics identify explainable gut microbial variants associated with Crohn's disease.

PloS one - 1 Jan 2026

Khan Nadeem, Nasir Muhammad Muneeb, Aziz Ubair, Manzoor Haseeb, Raziq Muhammad Faheem, Hussain Zamir, Jabeen Ishrat, Kayani Masood Ur Rehman

Abstract excerpt

Metagenomics has revealed disease-associated shifts in microbial taxa and functions in inflammatory bowel disease (IBD) patients. However, the role of genomic variation in gut commensals remains poorly understood. Here, we integrated metagenomic profiling, variant calling, and structural bioinformatics to identify disease-associated variants in the gut microbes. Crohn's disease (CD) and ulcerative colitis (UC)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42430408
DOI: 10.1371/journal.pone.0340748
PMCID: PMC13354076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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