Article
Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.
Gut - 1 Feb 2021
Hu Shixian, Vich Vila Arnau, Gacesa Ranko, Collij Valerie, Stevens Christine, Fu Jack M, Wong Isaac, Talkowski Michael E, Rivas Manuel A, Imhann Floris, Bolte Laura, van Dullemen Hendrik, Dijkstra Gerard, Visschedijk Marijn C, Festen Eleonora A, Xavier Ramnik J, Fu Jingyuan, Daly Mark J, Wijmenga Cisca, Zhernakova Alexandra, Kurilshikov Alexander, Weersma Rinse K
Abstract excerpt
OBJECTIVE: Both the gut microbiome and host genetics are known to play significant roles in the pathogenesis of IBD. However, the interaction between these two factors and its implications in the aetiology of IBD remain underexplored. Here, we report on the influence of host genetics on the gut microbiome in IBD. DESIGN: To evaluate the impact of host genetics on the gut microbiota of patients with IBD, we...
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