Article
Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings
2021-12-09
Abstract excerpt
Recent studies have revealed a role for zinc in insulin secretion and glucose homeostasis. Randomized placebo-controlled zinc supplementation trials have demonstrated improved glycemic traits in patients with type II diabetes (T2D). Moreover, rare loss-of-function variants in the zinc efflux transporter SLC30A8 reduce T2D risk. Despite this accumulated evidence, mechanistic understanding of how zinc influences sy...
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Identifiers and source
- Literature Corpus work
- b19daebc-9ef5-50ca-bd93-5b564465248e
- DOI
- 10.1101/2021.12.08.21267440