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Article

SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.

Science China. Life sciences - 1 Jul 2025

Shao Yichang, Mu Qingdian, Wang Rong, Luo Hongbin, Song Zijun, Wang Pengfei, Song Jingshu, Ge Chaodong, Zhang Jiyan, Min Junxia, Wang Fudi

Abstract excerpt

Zinc homeostasis plays an essential role in maintaining immune function and is tightly regulated by zinc transporters. We previously reported that the zinc transporter SLC39A10, located in the cell membrane, critically regulates the susceptibility of macrophages to inflammatory stimuli; however, the functional role of SLC39A10 in T cells is currently unknown. Here, we identified two SNPs in SLC39A10 that are...

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Source

Identifiers

PMID: 39862347
DOI: 10.1007/s11427-024-2817-y

Genes

SLC39A10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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