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Article

Loss-of-function SLC30A2 mutants are associated with gut dysbiosis and alterations in intestinal gene expression in preterm infants.

Gut microbes - 1 Jan 2000

Kelleher Shannon L, Alam Samina, Rivera Olivia C, Barber-Zucker Shiran, Zarivach Raz, Wagatsuma Takumi, Kambe Taiho, Soybel David I, Wright Justin, Lamendella Regina

Abstract excerpt

Loss of Paneth cell (PC) function is implicated in intestinal dysbiosis, mucosal inflammation, and numerous intestinal disorders, including necrotizing enterocolitis (NEC). Studies in mouse models show that zinc transporter ZnT2 (SLC30A2) is critical for PC function, playing a role in granule formation, secretion, and antimicrobial activity; however, no studies have investigated whether loss of ZnT2 function is...

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Identifiers

PMID: 34965180
DOI: 10.1080/19490976.2021.2014739
PMCID: PMC8726655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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