Article
Mutation in the S gene a determinant of the hepatitis B virus associated with concomitant HBsAg and anti-HBs in a population in Northeastern Brazil.
Journal of medical virology - 1 Mar 2017
de Campos Albuquerque Ingrid, Sousa Marinilde Teles, Santos Max Diego Cruz, Nunes Jomar Diogo Costa, Moraes Maria Josélia Diniz, Gomes-Gouvêa Michele Soares, Pinho João Renato Rebelo, Carrilho Flair José, Fonseca Lena Maria Barros, de Sousa Paiva Ferreira Adalgisa
Abstract excerpt
Mutations in the a determinant of S gene may develop co-existence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) in the serum of infected hepatitis B virus (HBV) individuals. Mutations in this region may change the antigenicity of HBsAg, which in turn, lead to escape of neutralizing action of anti-HBs antibodies. This study identified individuals with concomitant HBsAg and anti-HBs...
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