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Article

Molecular Insights Into the S Gene of Hepatitis B Virus: Analysis Among Household Contacts and Clinical Implications of Mutations.

Journal of viral hepatitis - 1 Jan 2026

Athalye Shreyasi, Khargekar Naveen, Panale Priyanka, Shinde Shailesh, Shankarkumar Aruna, Banerjee Anindita

Abstract excerpt

Occult hepatitis B infection (OBI) represents a unique diagnostic and clinical challenge due to undetectable HBsAg despite HBV DNA presence. Genetic mutations, particularly in the HBV S gene, play a crucial role in immune evasion and diagnostic failures associated with OBI. This cross-sectional study investigated the genetic mutations in the S gene of HBV among family members of chronically infected patients....

Read the complete abstract on PubMed

Topics

Humans
Hepatitis B virus
Male
Female
Cross-Sectional Studies
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hepatitis B Surface Antigens

Middle Aged

Mutation

DNA, Viral

Young Adult

Genotype

Adolescent

Hepatitis B Antibodies

Hepatitis B, Chronic

Hepatitis B

Family Characteristics

Aged

Source

Identifiers

PMID: 41424401
DOI: 10.1111/jvh.70124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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