Article
Prevalence of hepatitis B virus MHR mutations and their correlation with genotypes and antiviral therapy in chronically infected patients in Serbia.
Journal of medical virology - 1 Jul 2010
Lazarevic Ivana, Cupic Maja, Delic Dragan, Svirtlih Neda Stojkovic, Simonovic Jasmina, Jovanovic Tanja
Abstract excerpt
Understanding the prevalence and diversity of HBsAg variants in a population is fundamental to assay design and planning vaccination programs. It has been shown that mutations within the S gene, caused by selection or natural variation, can lead to false-negative results in assays for HBsAg, or have clinical implications, such as evading anti-HBV immunoglobulin therapy or vaccine-induced immunity. The region of...
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