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Article

NPM1-mutated acute myeloid leukemia: from bench to bedside.

Blood - 8 Oct 2020

Falini Brunangelo, Brunetti Lorenzo, Sportoletti Paolo, Martelli Maria Paola

Abstract excerpt

The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations represent the most common genetic lesion in adult acute myeloid leukemia (AML; about one third of cases), and they act deterministically to cause the aberrant cytoplasmic delocalization of NPM1 mutants. Because of its unique features, NPM1-mutated...

Topics

Animals
Cell Transformation, Neoplastic
Clonal Hematopoiesis
Disease Management
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Leukemia, Myeloid, Acute
Mutation
Nuclear Proteins
Nucleophosmin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precancerous Conditions

Prognosis

Translational Research, Biomedical

Source

Identifiers

PMID: 32609823
DOI: 10.1182/blood.2019004226

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