Article
Biological characteristics of the A1762T/G1764A mutant strain of hepatitis B virus in vivo.
Molecular medicine reports - 1 Oct 2015
Leng Xiao-Hua, Chen En-Qiang, Du Ling-Yao, Bai Lang, Gong Dao-Ying, Cheng Xing, Huang Fei-Jun, Tang Hong
Abstract excerpt
The double nucleotide, A1762T and G1764A exchange (TA mutation), in the hepatitis B virus (HBV) genome basal core promoter (BCP) region is a common viral mutation in patients with chronic HBV infection. This mutation is located in the binding site of hepatocyte nuclear factor 4 (HNF4), and a number of liver‑enriched transcription factors are involved in the regulation of HBV transcription and replication. The aim...
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