Article
Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections.
Virology - 15 Dec 1996
Moriyama K, Okamoto H, Tsuda F, Mayumi M
Abstract excerpt
Hepatitis B virus variants harboring nucleotide alterations in the preC-C promoter have been detected in fulminant hepatitis B as well as in HBeAg-seronegative persistent infection. However, it has not been demonstrated that variants with nucleotide alterations in the preC-C promoter cause variou...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- DNA, Viral
- Hepatitis B
- Hepatitis B e Antigens
- Hepatitis B virus
- Humans
- Molecular Sequence Data
- Phenotype
- Point Mutation
- Promoter Regions, Genetic
- RNA, Messenger
- RNA, Viral
- Transcription, Genetic
- Virus Replication