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Article

Development of neuro-fuzzy model to explore gene-nutrient interactions modulating warfarin dose requirement.

Pharmacogenomics - 1 Aug 2016

Pavani Addepalli, Naushad Shaik Mohammad, Lakshmitha Ganapathy, Nivetha Sriraman, Stanley Balraj Alex, Malempati Amaresh Rao, Kutala Vijay Kumar

Abstract excerpt

AIM: To investigate the influence of alterations in vitamin K (K1, K2 and K3) in modulating warfarin dose requirement. PATIENTS & METHODS: Reverse phase HPLC to determine the plasma vitamin K; PCR-RFLP to detect polymorphisms; and the neuro-fuzzy model to predict warfarin dose were used. RESULTS: The developed neuro-fuzzy model showed a mean absolute error of 0.000024 mg/week. CYP2C9*2 and CYP2C9*3 mediated...

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Source

Identifiers

PMID: 27462768
DOI: 10.2217/pgs-2016-0058

Genes

GGCX
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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