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Article

Retrospective evidence for clinical validity of expanded genetic model in warfarin dose optimization in a South Indian population.

Pharmacogenomics - 1 Jun 2012

Pavani Addepalli, Naushad Shaik Mohammad, Mishra Ramesh C, Malempati Amaresh Rao, Pinjala Ramakrishna, Kumar Takallapally Ramesh, Kutala Vijay Kumar

Abstract excerpt

AIM: To optimize warfarin dose in patients at risk for thrombotic events, we have recently developed a pharmacogenomic algorithm, which explained 44.9% of the variability in warfarin dose requirements using age, gender, BMI, vitamin K intake, CYP2C9 (*2 and *3) and VKORC1 (*3, *4 and -1639 G>A) as predictors. The aim of the current study is to develop an expanded genetic model that can explain greater percentage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22676192
DOI: 10.2217/pgs.12.62

Genes

GGCX
VKORC1

Variants

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