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Article

Plasma vitamin K concentrations depend on CYP4F2 polymorphism and influence on anticoagulation in Japanese patients with warfarin therapy.

Thrombosis research - 1 May 2015

Hirai Keita, Yamada Yuto, Hayashi Hideki, Tanaka Masaki, Izumiya Kohei, Suzuki Masayuki, Yoshizawa Misa, Moriwaki Hideaki, Akimoto Takehide, Tsuji Daiki, Inoue Kazuyuki, Itoh Kunihiko

Abstract excerpt

INTRODUCTION: Warfarin is characterized by a large inter-individual variability in dosage requirement. This study aimed to analyze the contribution of the CYP4F2 genetic polymorphism and plasma vitamin K concentration on the warfarin pharmacodynamics in patients and to clarify the plasma vitamin K concentration affecting warfarin sensitivity index in rats. MATERIALS AND METHODS: Genetic analyses of selected genes...

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Source

Identifiers

PMID: 25747538
DOI: 10.1016/j.thromres.2015.02.019

Genes

VKORC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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