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Amyloid precursor protein cooperates with c-KIT mutation/overexpression to regulate cell apoptosis in AML1-ETO-positive leukemia via the PI3K/AKT signaling pathway.

Oncology reports - 1 Sept 2016

Yu Guopan, Yin Changxin, Jiang Ling, Zheng Zhongxin, Wang Zhixiang, Wang Chunli, Zhou Hongsheng, Jiang Xuejie, Liu Qifa, Meng Fanyi

Abstract excerpt

It has been reported that amyloid precursor protein (APP) promotes cell proliferation and metastasis in various types of solid cancers. In our previous study, we showed that APP is highly expressed and regulates leukemia cell migration in AML1‑ETO-positive (AE) leukemia. Whether APP is involved in the regulation of AE leukemia cell proliferation or apoptosis is unclear. In the present study we focused on the...

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Share to Amyloid beta-Protein Precursor
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Leukemia, Myeloid, Acute

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins c-kit

Share to RUNX1 Translocation Partner 1 Protein

Source

Identifiers

PMID: 27460334
DOI: 10.3892/or.2016.4963

Genes

APP
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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