Article
AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2005
Wang Yue-Ying, Zhou Guang-Biao, Yin Tong, Chen Bing, Shi Jing-Yi, Liang Wen-Xue, Jin Xiao-Long, You Jian-Hua, Yang Guang, Shen Zhi-Xiang, Chen Jue, Xiong Shu-Min, Chen Guo-Qiang, Xu Feng, Liu Yi-Wei, Chen Zhu, Chen Sai-Juan
Abstract excerpt
To explore the genetic abnormalities that cooperate with AML1-ETO (AE) fusion gene to cause acute myeloid leukemia (AML) with t(8;21), we screened a number of candidate genes and identified 11 types of mutations in C-KIT gene (mC-KIT), including 6 previously undescribed ones among 26 of 54 (48.1%) cases with t(8;21). To address a possible chronological order between AE and mC-KIT, we showed that, among patients...
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