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Article

AEG-1 overexpression is essential for maintenance of malignant state in human AML cells via up-regulation of Akt1 mediated by AURKA activation.

Cellular signalling - 1 Jun 2013

Long Min, Hao Miaowang, Dong Ke, Shen Jianjun, Wang Xi, Lin Fang, Liu Li, Wei Junxia, Liang Yingmin, Yang Jian, Gu Fangna, Zhang Huizhong

Abstract excerpt

Acute myeloid leukemia (AML) remains highly fatal, highlighting the need for improved understanding of signal pathways that can lead to the development of new therapeutic regimens targeting common molecular pathways shared across different AML subtypes. Here we demonstrate that astrocyte elevated gene-1 (AEG-1) is one of such pathways, involving in cell cycle and apoptosis regulation and contributing to enhanced...

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Identifiers

PMID: 23499911
DOI: 10.1016/j.cellsig.2013.03.001

Genes

AURKA
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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