Article
Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells.
Cancer research - 1 May 2009
Faderl Stefan, Pal Ashutosh, Bornmann William, Albitar Maher, Maxwell David, Van Quin, Peng Zhenghong, Harris David, Liu Zhiming, Hazan-Halevy Inbal, Kantarjian Hagop M, Estrov Zeev
Abstract excerpt
Kit is a membrane-bound tyrosine kinase and receptor for stem cell factor (SCF) with a crucial role in hematopoiesis. Mutations of KIT occur in almost half of patients with core-binding factor leukemias, in which they have been associated with worse outcome. Development of new compounds targeting Kit may therefore hold promise for therapy. We investigated the activity and mechanism of action of APcK110, a novel...
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