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Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of <i>APP</i> , <i>ETS2</i> , and <i>ERG</i> genes

8 Mar 2004

Abstract excerpt

Molecular mechanisms of leukemogenesis have been successfully unraveled by studying genes involved in simple rearrangements including balanced translocations and inversions. In contrast, little is known about genes altered in complex karyotypic abnormalities. We studied acute myeloid leukemia (AML) patients with complex karyotypes and abnormal chromosome 21. High-resolution bacterial artificial chromosome (BAC)...

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PMID: 15007164
DOI: 10.1073/pnas.0400272101

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Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of <i>APP</i> , <i>ETS2</i> , and <i>ERG</i> genesPMID 15007164Read ↗

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