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Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway

13 Nov 2019

Abstract excerpt

To verify whether amyloid precursor protein (APP) affects the migration and invasion of breast cancer cell lines, and to understand its underlying mechanisms, epithelial‑mesenchymal transition (EMT), the mitogen‑activated protein kinase (MAPK) signaling pathway and the matrix metalloproteinase (MMP) family were investigated in MDA‑MB‑231, MCF‑7 and BT474 human breast cancer cells. Breast cancer cell lines were...

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PMID: 31746365
DOI: 10.3892/ijmm.2019.4404

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